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External Links. PubChem By a further functionalization of glass slides with hyaluronic acid it was possible compound anisomelic acid using chitosan-coated porous silica nanorods for 42, 2015. Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect. Targeted delivery of a novel anticancer compound anisomelic acid using acid functionalized mesoporous silica catalysts for esterification of fatty acids. 19 Feb 2018 acetoxy malabaric acid and anisomelol are isolated as macrocyclic diterpenes, while anisomelic acid, ovatodlolide are as diterpenoid lactones, 19 Dec 2013 Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic 8 Jul 2014 acid activates the PKR pathway and induces apoptosis through diterpenoid anisomelic acid causes depletion of E6 and E7 viral. 20 Jan 2009 Mohammad A. Akbarsha, Sakari Hietanen, John E. Eriksson, Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 24 Jun 2019 amines, acid anhydride and carboxylic compounds. Characterization revealed the presence of phyto compound such as aniso melic acid, 22 May 2019 as anisomelic acid, anisomeloide, ovatodiolide, 2-acetoxymalabaric acid, anisomelyl acetate anisomelin, betulinic acid, citral, gerainic acid, 24 Nov 2017 Novel action modality of the diterpenoid anisomelic acid causes depletion · of E6 and E7 viral oncoproteins in HPV-transformed cervical Aldrich-331562; Cyclohexanepentanoic acid 0.98; CAS No.: 5962-88-9; Synonyms: 5-Cyclohexylvaleric acid; Linear Formula: C6H11(CH2)4CO2H; Empirical 30 Jul 2018 Title: Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas.

S1†) is a diterpenoid compound isolated from the medicinal plant Anisomeles malabarica,7 which we have previously shown to be cytotoxic to oral and cervical Anisomelic acid, is one of the major compounds in Anisomeles malabarica (L.) R. Br., is a cembrane type diterpenoid, which can be synthesized chemically. Anisomeles malabarica (Lamiaceae) is an aromatic, densely pubescent, perennial herb, 1.2-2 m in height. The leaves of Anisomeles malabarica are used against colic, convulsion and tetanus. 2. Anisomelic acid (AA) (Fig.

DiVA - Sökresultat - DiVA Portal

Anisomeles malabarica has been shown to possess Anisomelic Acid, as well as Anisomelolide, Malabaric Acid, 2-Acetoxymalabaric Acid, Anisomelyl Acetate and Anisomelol (Preethy et al. 2013), and essential oils. Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species. Recently, we have shown that AA possesses both anti-cancer and anti-viral activity.

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Activities (1) ACE-Inhibitor 20 ug (weak activity) BETULINIC-ACID Plant -- 100.0 -0.63 Pavannasasivam, G., & M.U.S. Sultanbawa. 1974. Betulinic acid in the Dilleniaceae and a review of its natural distribution. Phytochem. 13:2002-2006. Activities (22) Anthelmintic AntiHIV EC50=2.0 ug/ml Kashiwada, Y terpenoid compounds, including Anisomelic Acid (Arisawa et al.

Yury Brusentsev, Abo may be due to the presence of volatile compounds such as anisomelic acid, betulinic acid, citral, gerainic acid and ovatodiolide in the plant extract (Guha Bakshi Pharmaceutical compositions of anisomelic acid and their use Download PDF pharmaceutical composition: cells: antiviral: apoptosis: anisomelic acid; Prior art Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas.
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Anisomelic acid (AA) (Fig. S1†) is a diterpenoid compound isolated from the medicinal plant Anisomeles malabarica, 7 which we have previously shown to be cytotoxic to oral and cervical cancer cells. 8 Recently, we have shown that AA induces apoptosis and cause cell cycle arrest in SiHa cervical cancer cells by specifically down-regulating the viral oncoproteins, E6 and E6, 9,10 which are the Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof. The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a 2019-05-23 · The essential oil of the plant is useful in uterine affections (6). The plant yields anisomelic acid, ovatodiolide, 4,7-epoxyovatodiolide, apigenin, terniflorin B, prunin-6”-p-comarate, maslinic acid, hederagenin, and arjunolic acid (6,7).

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Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas Rajendran Senthilkumar , Yury Brusentsev , +4 authors J. Eriksson Scientific Reports Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells. The MTT assay for cell viability indicated that AA is cytotoxic to all of the four cell lines tested in a dose- and duration-dependent manner.

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Publikationslista för Magnus Odén - Publication List : Epress : LiU.se

Anisomeles malabarica (Lamiaceae) is an aromatic, densely pubescent, perennial herb, 1.2-2 m in height.

Targeted delivery of a novel anticancer compound anisomelic

Here, we describe the molecular interactions of AA with two serum proteins, human serum albumin (HSA) and bovine serum albumin (BSA Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles mal - abarica . Recently, we have studied the mode of action of AA-mediated apoptosis Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Annual Congress on Medicinal Chemistry, Pharmacology and toxicology July 30 - 31 , 2018 Amsterdam , Netherlands.

The present study describes the structure-activity relationship and the evaluation of synthetic AA like compounds, i.e simplified cembranoid-like structures, as HPV inhibitors against some papilloma cell lines.